- Patent Title: Transduced T cells expressing human SSTR2 and application thereof
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Application No.: US15675419Application Date: 2017-08-11
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Publication No.: US10577408B2Publication Date: 2020-03-03
- Inventor: Moonsoo Jin
- Applicant: Cornell University
- Applicant Address: US NY Ithaca
- Assignee: Cornell University
- Current Assignee: Cornell University
- Current Assignee Address: US NY Ithaca
- Agency: Perkins Coie LLP
- Agent Viola T. Kung
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C12P21/08 ; C07K14/72 ; A61K38/17 ; A61K51/08 ; A61K39/00 ; A61K35/17 ; C07K14/725 ; C07K14/705 ; C12N5/0783
Abstract:
The present invention is directed to transduced T cells expressing at least 100,000 molecules of human somatostatin receptor 2 (SSTR2), which improves PET/CT imaging sensitivity. The present invention is also directed to transduced T cells expressing SSTR2 and chimeric antigen receptor (CAR). In one embodiment, the CAR is specific to human ICAM-1 and the CAR comprises a binding domain that is scFv of anti-human ICAM-1, or an I domain of the αL subunit of human lymphocyte function-associated antigen-1. In another embodiment, the CAR is specific to human CD19, and the CAR comprises a binding domain that is scFv of anti-human CD19. The present invention is further directed to using the above transduced T cells for monitoring T cell distribution in a patient by PET/CT imaging and/or treating cancer.
Public/Granted literature
- US20180066037A1 TRANSDUCED T CELLS EXPRESSING HUMAN SSTR2 AND APPLICATION THEREOF Public/Granted day:2018-03-08
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