Invention Grant
- Patent Title: Peptide regulators of mitochondrial fusion and methods of use
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Application No.: US15710696Application Date: 2017-09-20
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Publication No.: US10578610B2Publication Date: 2020-03-03
- Inventor: Daria Mochly-Rosen , Gerald W. Dorn, II
- Applicant: The Board of Trustees of the Leland Stanford Junior University , Washington University
- Applicant Address: US MO St. Louis US CA Stanford
- Assignee: Washington University,Stanford University
- Current Assignee: Washington University,Stanford University
- Current Assignee Address: US MO St. Louis US CA Stanford
- Main IPC: C07K7/08
- IPC: C07K7/08 ; C07K14/705 ; G01N33/50 ; C12N9/14 ; G01N33/547 ; G01N33/566 ; G01N33/58 ; A61K38/00
Abstract:
Mitofusin modulatory peptides are described which may function as activators or inhibitors of mitochondrial fusion. The sequences and compositions comprising the sequences are useful for treating diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2) and mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations and methods of identifying compounds that mimic the activity of the peptides for use in screening assays are also described.
Public/Granted literature
- US20180080926A1 PEPTIDE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE Public/Granted day:2018-03-22
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