A gas cylinder lease system is disclosed, comprising one or more lease equipments and a cloud server equipment, wherein the inside of the lease equipment is installed with at least one placement rack area for accommodating the gas cylinder; accordingly, after any one of the lease equipments has been rented and at least one gas cylinder has been taken out, the renter may subsequently return the used gas cylinder to the lease main rack located at the same or different locations, with the use status of each placement rack area being uploaded to the cloud server equipment in real-time thereby monitoring the operation status of each lease equipment and executing corresponding replenishment and maintenance tasks in a timely fashion.