The present disclosure relates to a drive method of a liquid crystal display device, including: displaying each picture sequentially by using two frames of images, where two adjacent sub-pixels on each frame of image have a high drive voltage and a low drive voltage; determining a backlight lightness adjustment signal of each backlight subarea according to drive voltages of a first frame of image area and a second frame of image area corresponding to each backlight subarea and a first frame of image area and a second frame of image area corresponding to backlight subareas adjacent to the backlight subarea; and performing independent lightness adjustment on a backlight source of various types of the color sub-pixels in a corresponding backlight subarea in each frame of image of a next picture according to the backlight lightness adjustment signal of each backlight subarea.