A surgical instrument that includes a surgical end effector that is articulatable relative to an elongate shaft. The end effector includes a first jaw and a second jaw. The second jaw is movable between an open position and closed positions when a closure member is moved in a closing direction. An articulation lock is configured to move from a locked configuration wherein the end effector is prevented from articulating and an unlocked configuration wherein the end effector is articulatable. The articulation lock is configured to move from the locked configuration to the unlocked configuration when the closure member is moved from the open position in the closing direction.