A handling device for a micro-invasive surgical instrument includes a gripping device, a shaft coupling, and a rod coupling. The gripping device is configured to guide and hold the handling device. The shaft coupling is configured to detachably couple a proximal end of a shaft to the handling device. The rod coupling is configured to slide in the handling device between an assembly position and a range of working positions to detachably couple a proximal end of a transmission rod to the handling device. The transmission rod is disposed in the shaft. The shaft coupling is configured to block the proximal end of the shaft in a predetermined position in which the proximal end of the shaft holds the rod coupling in the range of working positions.