Invention Grant
- Patent Title: Oxo-M and 4-PPBP induction of tenogenic differentiation of perivascular tendon stem cells
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Application No.: US16133076Application Date: 2018-09-17
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Publication No.: US10583117B2Publication Date: 2020-03-10
- Inventor: Chang Hun Lee , Solaiman Tarafder , Esther Chen
- Applicant: The Trustees of Columbia University in the City of New York
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Beusse Wolter Sanks & Maire
- Agent Timothy Van Dyke
- Main IPC: A61K31/4015
- IPC: A61K31/4015 ; A61P31/00 ; A61P37/06 ; A61K9/16 ; A61L27/18 ; A61L27/54 ; A61K31/196 ; A61K9/00 ; A61L27/56 ; B33Y80/00
Abstract:
Provided herein are compositions including oxotremorine (e.g., oxotremorine methiodide or Oxo-M) and 4-PPBP (e.g., 4-PPBP maleate). Also provided are methods of treating a connective tissue defect in a subject with oxotremorine and 4-PPBP. In addition, provided are scaffolds and methods of making same that include multiple fibers that include Oxo-M, 4-PPBP, and optionally icariin or kartogenin.
Public/Granted literature
- US20190015386A1 Oxo-M and 4-PPBP induction of tenogenic differentiation of perivascular tendon stem cells Public/Granted day:2019-01-17
Information query
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