Invention Grant
- Patent Title: Methods and compositions for immune protection against extra-intestinal pathogenic E. coli
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Application No.: US15754867Application Date: 2016-08-24
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Publication No.: US10583185B2Publication Date: 2020-03-10
- Inventor: Jan Theunis Poolman , Bert Jacquemyn , Darren Robert Abbanat , Patricia Ibarra Yon , Peter Wilhelmus Maria Hermans , Michael Thomas Kowarik , Michael Lukas Wetter , Stefan Jochen Kemmler , Micha Andres Häuptle , Veronica Gambillara Fonck , Manuela Mally
- Applicant: GlaxoSmithKline Biologicals S.A. , Janssen Pharmaceuticals, Inc.
- Applicant Address: BE Rixensart US NJ Titusville
- Assignee: GlaxoSmithKline Biological S.A.,Janssen Pharmaceuticals, Inc.
- Current Assignee: GlaxoSmithKline Biological S.A.,Janssen Pharmaceuticals, Inc.
- Current Assignee Address: BE Rixensart US NJ Titusville
- Agency: Panitch Schwarze Belisario & Nadel LLP
- International Application: PCT/US2016/048278 WO 20160824
- International Announcement: WO2017/035181 WO 20170302
- Main IPC: A61K39/108
- IPC: A61K39/108 ; A61K47/64 ; A61P31/04 ; A61K39/385 ; C08B37/00 ; A61K39/00
Abstract:
Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, O2, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, O2, O6A and O25B.
Public/Granted literature
- US20180243393A1 METHODS AND COMPOSITIONS FOR IMMUNE PROTECTION AGAINST EXTRA-INTESTINAL PATHOGENIC E. COLI Public/Granted day:2018-08-30
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