- Patent Title: Efficient delivery of therapeutic molecules in vitro and in vivo
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Application No.: US15518183Application Date: 2015-10-09
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Publication No.: US10583201B2Publication Date: 2020-03-10
- Inventor: Zheng-Yi Chen , David Liu
- Applicant: Massachusetts Eye and Ear Infirmary
- Applicant Address: US MA Boston
- Assignee: Massachusetts Eye and Ear Infirmary
- Current Assignee: Massachusetts Eye and Ear Infirmary
- Current Assignee Address: US MA Boston
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Nicholas A. Zachariades; Ingrid A. Beattie
- International Application: PCT/US2015/000109 WO 20151009
- International Announcement: WO2016/057061 WO 20160414
- Main IPC: C12Q1/10
- IPC: C12Q1/10 ; A61K49/22 ; A61K48/00 ; A61K9/127 ; A61K9/00 ; C12N15/10 ; C12N15/11 ; A61P27/16 ; A61K38/45 ; A61K38/46 ; C12N9/12 ; C12N9/22 ; A61K38/00
Abstract:
A chimeric molecule of one or more proteins or peptides fused, complexed or linked to one or more anionic molecules. Efficient in vitro and in vivo delivery is attained by encapsulating these molecules in cationic lipids or cationic liposomes. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.
Public/Granted literature
- US20170326254A1 Efficient delivery of therapeutic molecules in vitro and in vivo Public/Granted day:2017-11-16
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