Embodiments of the disclosure relate to systems and methods for detecting driver state based on glucose levels of a driver of the vehicle. In one embodiment, a method of detecting driver state based on glucose levels of a driver of the vehicle includes receiving measurements of glucose levels of the driver from a continuous glucose monitoring (CGM) device and determining a glycemic state of the driver based on the measurements and a driving performance parameter based on the glycemic state. The method further includes determining a degree of impairment of the driver based on whether the driving performance parameter satisfies a predetermined threshold and determining a level of driver state severity based on driver performance characteristics, features of the driving environment, and the degree of impairment of the driver. A response is then activated based on the driver state severity.