A method and an apparatus for filling capsules with loose material and for their sealing, in which the plates equipped with a plurality of housings designed to accommodate respective capsules are carried on after another, by conveyor devices, to a plurality of operating stations, at each of which the capsules relative to each plate are subjected to respective manipulations by at least one manipulating device; the plates being supported in a removable manner by the conveyor means, and at each operating station there being a device for locking the plates which can be activated by a management unit, for stopping at least one plate at a time at the operating station for a predetermined time for it to be manipulated by at least one manipulating device and for releasing at least one plate at a time at the end of the manipulating of the at least one manipulating device.