Invention Grant
- Patent Title: Expression of Klebsiella oxytoca polypeptides involved in lysine decarboxylation, and methods and applications thereof
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Application No.: US15547323Application Date: 2015-01-30
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Publication No.: US10584149B2Publication Date: 2020-03-10
- Inventor: Howard Chou , Naiqiang Li , Xiucai Liu
- Applicant: CATHAY R&D CENTER CO., LTD. , CATHAY INDUSTRIAL BIOTECH LTD.
- Applicant Address: CN Shanghai US DE Newark
- Assignee: Cathay Biotech Inc.,CIBT America Inc.
- Current Assignee: Cathay Biotech Inc.,CIBT America Inc.
- Current Assignee Address: CN Shanghai US DE Newark
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- International Application: PCT/CN2015/071978 WO 20150130
- International Announcement: WO2016/119230 WO 20160804
- Main IPC: C07K14/195
- IPC: C07K14/195 ; C12N9/88 ; C12P13/00 ; C12N5/10 ; C12N15/70 ; C12P21/02
Abstract:
Provided are lysine decarboxylase polypeptides comprising mutants of SEQ ID NO: 2 and/or fragments thereof. The mutants or fragments have at least 95% sequence identity with SEQ ID NO: 2. Also provided are DNA polynucleotides encoding said lysine decarboxylases, expression vector comprising the DNA polynucleotides, transformants, mutant host cells, methods for the production of lysine decarboxylases, and methods for the production of a lysine-derived product.
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