Invention Grant
- Patent Title: Humanized monoclonal antibodies and methods of use
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Application No.: US15236279Application Date: 2016-08-12
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Publication No.: US10584172B2Publication Date: 2020-03-10
- Inventor: Wayne Marasco , Jianhua Sui , Quan Zhu , Thomas Kupper
- Applicant: DANA-FARBER CANCER INSTITUTE, INC. , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- Applicant Address: US MA Boston US MA Boston
- Assignee: DANA FARBER CANCER INSTITUTE, INC.,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- Current Assignee: DANA FARBER CANCER INSTITUTE, INC.,THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Baker Donelson
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K16/28 ; C07K14/715 ; C07K16/30
Abstract:
The present invention comprises a humanized monoclonal antibody that binds to the chemokine receptor CCR4. This antibody is derived from Mab 1567 and recognizes the same epitope. Binding of the invented antibody to CCR4 inhibits ligand-mediated activities and is used to treat symptoms of cancer. Moreover, the antibody is used in combination with vaccines to suppress the activity of regulatory T cells.
Public/Granted literature
- US20170044262A1 HUMANIZED MONOCLONAL ANTIBODIES AND METHODS OF USE Public/Granted day:2017-02-16
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