- Patent Title: Cell-based methods for measuring activity of a protein inhibitor
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Application No.: US14153383Application Date: 2014-01-13
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Publication No.: US10584369B2Publication Date: 2020-03-10
- Inventor: Igor B Roninson , Donald C Porter , Serena Altilia
- Applicant: Senex Biotechnology, Inc.
- Applicant Address: US SC Columbia
- Assignee: Senex Biotechnology, Inc.
- Current Assignee: Senex Biotechnology, Inc.
- Current Assignee Address: US SC Columbia
- Agency: Quarles & Brady LLP
- Main IPC: C12N9/12
- IPC: C12N9/12 ; C12Q1/48 ; G01N33/573 ; G01N33/50
Abstract:
The invention provides a method for determining the activity of an inhibitor of a target protein that has a deleterious effect on cell growth. The principle of the claimed method is that a compound that inhibits the function of an overexpressed protein will relieve the detrimental effect of such overexpression in a concentration-dependent manner, thereby allowing the determination of the activity of the compound in inhibiting its target protein in live cells.
Public/Granted literature
- US20140199708A1 CELL-BASED METHODS FOR MEASURING ACTIVITY OF A PROTEIN INHIBITOR Public/Granted day:2014-07-17
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