The present application relates to the technical field of photographing devices, and provides a centroid adjustment mechanism of a pan-tilt-zoom camera, a pan-tilt-zoom, and an aerial vehicle. The centroid adjustment mechanism includes: a camera base provided on a pan-tilt-zoom, and a slide platform located below the camera base, and further including: an X axis direction centroid adjustment mechanism, a Y axis direction centroid adjustment mechanism, and a Z axis direction centroid adjustment mechanism that adjust a camera centroid in three directions in a working manner of meshing a gear with a rack.