An obfuscation macro can expand obfuscation identification information into a data value during or prior to compiling source code, and insert a de-obfuscation call where the data value is referenced in the source code. An obfuscation utility can scan compiled binaries for data values containing obfuscation identification information. The obfuscation utility identifies and obfuscates data values containing obfuscation identification information within the compiled binaries. The de-obfuscation call de-obfuscates obfuscated data values during runtime.