Disclosed are systems, methods and computer program products for controlling access to operating system (OS) resources. An exemplary method includes: creating an OS resource associated with a first program; assigning a unique label to the first program; associating the unique label with the OS resource; and configuring a resource descriptor of the OS resource to allow access to the OS resource to processes having the same unique label as the first program, and to deny access to the OS resource to processes having a different label.