Advanced micro-location of RFID tags in 3D and 2D spatial environments includes a mobile platform having a known location within a three-dimensional (3D) space. A plurality of RFID tags is located within the 3D space. A plurality of RFID antennas is mounted on the mobile platform, wherein backscatter signals of at least one of the RFID tags are collected by at least one of the plurality of RFID antennas and time-synchronized with the known location of the mobile platform in the 3D space at a time of collection. A computerized processing device is in communication with the plurality of RFID antennas. The computerized processing device performs algorithmic RFID tag localization using at least the collected backscatter signals of the at least one RFID tag and the time-synchronized known location of the mobile platform to determine a micro-location of the at least one RFID tag within the 3D space.