In some embodiments, methods and systems are provided that provide for validating products to be delivered to customers via unmanned aerial vehicles. Each UAV includes sensors configured to detect at least one actual physical characteristic and/or actual identifying characteristic of a product being loaded into the UAV and/or being transported by the UAV to a delivery destination. The actual physical characteristic information and/or the actual identifying information detected by the sensors is compared to predefined physical characteristic information and/or predefined identifying information stored in an electronic database in order to validate that the product that is being loaded into the UAV and/or being transported by the UAV is not damaged and corresponds to the order being fulfilled. If validation of one or more products is not successful, the UAV is restricted from delivering such products to the delivery destination.