Sequence detectors and detection methods are provided for detecting symbol values corresponding to a sequence of input samples obtained from an ISI channel. The sequence detector comprises a branch metric unit (BMU) and a path metric unit (PMU). The BMU, which comprises an initial set of pipeline stages, is adapted to calculate, for each input sample, branch metrics for respective possible transitions between states of a trellis. To calculate these branch metrics, the BMU selects hypothesized input values, each dependent on a possible symbol value for the input sample and L>0 previous symbol values corresponding to possible transitions between states of the trellis. The BMU then calculates differences between the input sample and each hypothesized input value. The BMU compares these differences and selects, as the branch metric for each possible transition, an optimum difference in dependence on a predetermined state in a survivor path through the trellis.