A semi-persistent resource scheduling (SPS) allocation for a user equipment is deactivated in an LTE-based mobile communication system without requiring changes to the Physical layer-to-MAC layer interface and/or changes to PDCCH formats agreed by the 3GPP. A combination of a New Data Information (NDI) value and a modulation and coding scheme (MCS) index is defined that commands release of a SPS resource allocation. The modulation and coding scheme information in the predetermined combination includes an index of 11111 in binary format that indicates no transport block size information.