Techniques for creating a mesoporous surface for enhanced bone integration are provided. An example of a method for generating a mesoporous surface on a substrate includes depositing a layer of titanium on an area of the substrate to generate a nano-textured surface, and anodizing the layer of titanium on the area of the substrate to generate the mesoporous surface. The method may also include incorporating pharmaceutical, biological, or molecular additives into the mesoporous surface intended to further enhance performance of the substrate via enhanced osseoconduction, osseoinduction, or antimicrobial/anti-infective properties.