Invention Grant
- Patent Title: Process for the preparation of isosulfan blue
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Application No.: US16170510Application Date: 2018-10-25
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Publication No.: US10590071B2Publication Date: 2020-03-17
- Inventor: Ravishanker Kovi , Satyam Nampalli , Peter Xavier Tharial
- Applicant: Apicore US LLC
- Applicant Address: US PA Canonsburg
- Assignee: Apicore US LLC
- Current Assignee: Apicore US LLC
- Current Assignee Address: US PA Canonsburg
- Main IPC: C07C309/46
- IPC: C07C309/46 ; C07C303/22 ; C07C303/02

Abstract:
Isosulfan blue and processes for the preparation thereof are provided. A process is also provided for preparation of the intermediate, 2-chlorobenzaldehyde-5-sulfonic acid, sodium salt of formula (2), used in the preparation thereof and a procedure for the isolation of benzaldehyde-2,5-disulfonic acid, di-sodium salt of the formula (3). Also provided is a process for the preparation of an isoleuco acid of formula (4), which upon oxidation gives rise to isosulfan blue of pharmaceutical grade which can be used for preparation of pharmaceutical formulations. The isolation and purification procedures provided in the process provide substantially pure isosulfan blue with HPLC purity 99.5% or greater.
Public/Granted literature
- US20190062268A1 Process for the preparation of Isosulfan Blue Public/Granted day:2019-02-28
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