Invention Grant
- Patent Title: System for conditioning of engineered microtissues
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Application No.: US15528233Application Date: 2015-11-20
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Publication No.: US10590376B2Publication Date: 2020-03-17
- Inventor: Daniel H. Reich , Fan Xu , Ruogang Zhao , Alan S. Liu , Tristin Metz , Yu Shi
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: The Johns Hopkins University
- Current Assignee: The Johns Hopkins University
- Current Assignee Address: US MD Baltimore
- Agency: Johns Hopkins Technology Ventures
- International Application: PCT/US2015/061800 WO 20151120
- International Announcement: WO2016/081816 WO 20160526
- Main IPC: C12M1/42
- IPC: C12M1/42 ; C12M3/00 ; C12M1/32 ; C12M1/12 ; C12M1/00 ; C12M1/34 ; C12N13/00 ; B01L3/00

Abstract:
A system and method for conditioning a tissue are provided. The system includes a substrate, a plurality of microwells formed in the substrate, and a microsphere associated with each of the plurality of microwells. The system also includes a pair of flexible pillars within each of the plurality of microwells. Each flexible pillar includes a first end bonded to a respective microwell and at least one flexible pillar has a second end bonded to the microsphere. The flexible pillars are configured to deflect when exposed to a magnetic field to controllably stretch microtissue spanning the flexible pillars.
Public/Granted literature
- US20170362560A1 SYSTEM AND METHOD FOR CONDITIONING OF ENGINEERED TISSUES Public/Granted day:2017-12-21
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