Invention Grant
- Patent Title: Method of producing natural killer cells and composition for treating cancer
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Application No.: US16523964Application Date: 2019-07-26
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Publication No.: US10590385B2Publication Date: 2020-03-17
- Inventor: Sang Woo Park , Yong Man Kim , Jae Seob Jung , Yong-Hee Rhee
- Applicant: NKMAX Co., Ltd.
- Applicant Address: KR Gyeonggi-Do
- Assignee: NKMAX CO., LTD.
- Current Assignee: NKMAX CO., LTD.
- Current Assignee Address: KR Gyeonggi-Do
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Priority: KR10-2018-0012938 20180201; KR10-2018-0012942 20180201; KR10-2019-0001981 20190107; KR10-2019-0001983 20190107
- Main IPC: C12N5/0783
- IPC: C12N5/0783 ; A61K35/17 ; A61K38/20 ; A61P35/00
Abstract:
A method for producing natural killer cells is disclosed. The method comprises isolating peripheral blood mononuclear cells (PBMCs) from a blood sample; isolating at least one of CD56+ cells and/or CD3−/CD56+ cells from the PBMCs; and co-culturing the at least one of CD56+ cells and/or CD3−/CD56+ cells with a combination of feeder cells in the presence of a cytokine. A composition for treating cancer is also disclosed. The composition comprises the CD56+ natural killer cells produced by the disclosed method and a cytokine.
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