Invention Grant
- Patent Title: Process for modifying galactosylation and G0F content of a glycoprotein composition by glutamine supplementation
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Application No.: US15121361Application Date: 2015-02-24
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Publication No.: US10590455B2Publication Date: 2020-03-17
- Inventor: Sreenath Kadreppa , Madhava Ram Paranandi Ananta , Senthil Kumar Baskaran , Shinto Antony
- Applicant: DR. REDDY'S LABORATORIES LIMITED
- Applicant Address: IN Hyderabad
- Assignee: DR. REDDY'S LABORATORIES LIMITED
- Current Assignee: DR. REDDY'S LABORATORIES LIMITED
- Current Assignee Address: IN Hyderabad
- Agency: Pergament & Cepeda LLP
- Agent Milagros A. Cepeda; Edward D. Pergament
- Priority: IN928/CHE/2014 20140225
- International Application: PCT/IB2015/051367 WO 20150224
- International Announcement: WO2015/128795 WO 20150903
- Main IPC: C12P21/00
- IPC: C12P21/00 ; C07K16/22
Abstract:
The invention relates to a cell culture process for decreasing the galactosylated content and/or increasing the G0F content of a glycoprotein. The process involves subjecting recombinant cells expressing the said glycoprotein to a temperature and pH shift and supplementing cell culture with glutamine.
Public/Granted literature
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