Invention Grant
- Patent Title: Polymerase variants
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Application No.: US15443964Application Date: 2017-02-27
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Publication No.: US10590480B2Publication Date: 2020-03-17
- Inventor: Aruna Ayer , Preethi Sarvabhowman , Dhruti Vasudev Dalal
- Applicant: Roche Sequencing Solutions, Inc.
- Applicant Address: US CA Pleasanton
- Assignee: Roche Sequencing Solutions, Inc.
- Current Assignee: Roche Sequencing Solutions, Inc.
- Current Assignee Address: US CA Pleasanton
- Agency: Roche Sequencing Solutions, Inc.
- Main IPC: C12Q1/6869
- IPC: C12Q1/6869 ; C12N9/12

Abstract:
The present of disclosure provides variant Pol6 polymerase polypeptide, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.
Public/Granted literature
- US20180245147A1 POLYMERASE VARIANTS Public/Granted day:2018-08-30
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