The invention concerns a line guide device (100 . . . 1100) for lines like for example cables, hoses or the like, in particular for a clean room application, which has a flexible sheath (210 . . . 610). The sheath (210 . . . 1100) is designed in the manner of a corrugated tube and has a corrugated profile for the purposes of flexibility. The sheath (210 . . . 1100) has an asymmetric bending characteristic in relation to curvature about the direction-changing axis and to opposite curvature such that the permitted bending sag is considerably less than the desired curvature.According to an aspect there is proposed a particular configuration of shell portions (331, 332; 1031, 1032; 1201, 1202) for constructing the sheath, in particular in respect of the corrugated profiles and the fixing of the shell portions (1201, 1202).A further aspect concerns a supporting skeleton (440; 540; 640; 940) for a corrugated tube.