A method and associated system are provided for producing a perforation line between adjacent lottery tickets in an automated production line wherein a substrate having lottery tickets printed thereon is conveyed through a perforation station in the production line. A perforation machine in the line is controlled to define a perforation line between the adjacent lottery tickets. The controlling process includes inputting control variables into a controller associated with the perforation machine, the control variables relating to conditions that determine a desired perforation profile of the perforation line. The controller programs the perforation machine with a specific perforation profile for the perforation line that is generated based on the entered control variables, and changes the perforation profile upon inputting of different values for the control variables. The perforation profile is specifically tailored to the control variables between different ticket production runs, or between tickets in the same ticket production run.