Systems and methods for gesture sequence recognition using Simultaneous Localization and Mapping (SLAM) components in virtual, augmented, and mixed reality (xR) applications are described. In an illustrative, non-limiting embodiment, an Information Handling System (IHS) may include: a processor; and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution, cause the IHS to: detect a gesture performed by a user wearing a Head-Mounted Device (HMD) using a first image capture device and a second image capture device concurrently; evaluate the first and second image capture devices; identify the gesture based upon the evaluation; and execute a command associated with the gesture.