Methods and systems for securing memory within a computing fabric are disclosed. One method includes allocating memory of one or more host computing systems in the computing fabric to a partition, the partition included among a plurality of partitions, the computing fabric including a hypervisor installed on the one or more host computing platforms and managing interactions among the plurality of partitions. The method includes defining an address range associated with the memory allocated to the partition, receiving a memory operation including an address within the address range, and, based on the memory operation including an address within the address range, issuing, by the hypervisor, an indication that the memory operation is occurring at an encrypted memory location. The method also includes performing the memory operation, and performing an encryption operation on data associated with the memory operation.