A holistic hospital patient care and management system comprises a data store operable to receive and store patient data including clinical and non-clinical data; a plurality of video cameras to capture images of the patients; a plurality of presence detection sensors to detect the presence and location of the patients; a risk logic module configured to apply at least one predictive model to the clinical and non-clinical data, including the captured images, to determine at least one risk score associated with the patients; a facial biological change logic module configured to receive location data from the plurality of presence detection sensors, the risk score and medical condition associated with the patients, and captured images of the patients, and generating an alert in response to a detected change in biological change of a patient.