Methods and apparatus to prevent tampering with an x-ray tube are disclosed. An example circuit board device positioned with respect to the x-ray tube includes a processor and a memory. The example processor is to at least determine configuration information for the circuit board device. The example processor is to at least compare the determined configuration information to stored configuration information in the memory. The example processor is to at least, when the determined configuration information is verified with the stored configuration information, enable the circuit board device. The example processor is to at least, when the determined configuration information is not verified with the stored configuration information, i) disable the circuit board device and ii) process board reactivation before enabling the circuit board device.