The invention comprises a plurality of components, each of which impedes or prevents intrusion by bed bugs onto a bed or kill them upon contact. A fitted sheet, impenetrable to bed bugs is removeably attached to a slippery skirt, which is too smooth for a bed bug to climb. Together, these inhibit bed bugs from climbing to the top of the bed from the floor or through the mattress. Zippers to attach the fitted sheet and slippery skirt are designed to prevent small gaps. Headboard and footboard attachments of a slippery skirt design further prevent incursion and form passive traps for encroaching bed bugs. A pesticide infused second skirt attached to the slippery skirt around the bed springs actively kills bed bugs which contact it, reducing the number of bed bugs living in an infested mattress. All parts except the slippery skirts and pesticidal skirt may be washed or heated in a conventional dryer, killing invasive bed bugs, thereby permitting extended use, reuse and higher effectiveness of the invention.