A furniture frame structural system with interlocking members includes a first face frame, a second face frame, and a plurality of frame members. At least one joining feature for each frame member allows the frame members to arrange into a skeletal configuration as the joining feature includes a male interlocking portion and a female interlocking portion. More specifically, the male interlocking portion for each frame member is engaged with the female interlocking portion of an adjacent member from the frame members. Resultantly, the frame members complete the skeletal configuration. The first face frame and the second face frame are then oppositely mounted to the skeletal configuration completing the basic frame structure. Additional components such as post-tensioned fasteners, inner liners, outer panels held in side rails, a top, legs, and baseboard can be optionally integrated with the basic frame structure to improve the functionality and appearance of the resulting furniture.