The present disclosure provides a method of treating allergies and autoimmune diseases using microsystem acupuncture. Methods provided herein for treating allergies and autoimmune diseases using microsystem acupuncture involving a novel allergy zone. In embodiments, the method includes identifying an allergy zone (AZ) (Soliman Allergy Zone (SAZ)) (FIG. 1 A) in an acupuncture microsystem of a subject in need of treatment and treating the zone to treat the allergy or autoimmune disease. In embodiments, treating the zone includes introducing an acupuncture needle in the zone. In particular embodiments, the method includes identifying one or more active points in the liver projection site of the AZ and treating the active point or points.