Invention Grant
- Patent Title: Polymer conjugate of hexa-coordinated platinum complex
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Application No.: US15759295Application Date: 2016-09-08
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Publication No.: US10596191B2Publication Date: 2020-03-24
- Inventor: Masaharu Nakamura , Tsuyoshi Fukuda , Yusaku Kikuchi , Chihiro Watanabe
- Applicant: Nippon Kayaku Kabushiki Kaisha
- Applicant Address: JP Tokyo
- Assignee: Nippon Kayaku Kabushiki Kaisha
- Current Assignee: Nippon Kayaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Nields, Lemack & Frame, LLC
- Priority: JP2015-180875 20150914
- International Application: PCT/JP2016/076482 WO 20160908
- International Announcement: WO2017/047497 WO 20170323
- Main IPC: A61K33/24
- IPC: A61K33/24 ; A61K47/10 ; A61K47/34 ; A61P35/00 ; C07F15/00 ; C08G65/333 ; C08G65/337 ; C08G69/10 ; C08G69/40 ; C08G69/48

Abstract:
A DDS preparation of a platinum complex, which selectively releases a highly active platinum complex in cells that are under reducing conditions, and exhibits high antitumor activity that is required from a medicine, is still not available, and there is a demand for a novel DDS preparation of a platinum complex that may be used in clinical fields. There is provided a polymer conjugate of a hexa-coordinated platinum complex, the polymer conjugate comprising a block copolymer having a polyethylene glycol structural moiety and a polyaspartic acid moiety or a polyglutamic acid moiety; and a hexa-coordinated platinum complex having a halogen atom and a hydroxyl group at the axial positions, the hexa-coordinated platinum complex being bonded, directly or via a spacer, to a side-chain carboxyl group of the block copolymer.
Public/Granted literature
- US20180250332A1 Polymer Conjugate Of Hexa-Coordinated Platinum Complex Public/Granted day:2018-09-06
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