Invention Grant
- Patent Title: Stable, concentrated radionuclide complex solutions
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Application No.: US16175261Application Date: 2018-10-30
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Publication No.: US10596276B2Publication Date: 2020-03-24
- Inventor: Francesco de Palo , Lorenza Fugazza , Donato Barbato , Maurizio Mariani , Daniela Chicco , Giovanni Tesoriere , Clementina Brambati
- Applicant: Advanced Accelerator Applications (Italy) Srl
- Applicant Address: IT Pozzilli (Isernia)
- Assignee: ADVANCED ACCELERATOR APPLICATIONS (ITALY) S.R.L.
- Current Assignee: ADVANCED ACCELERATOR APPLICATIONS (ITALY) S.R.L.
- Current Assignee Address: IT Pozzilli (Isernia)
- Agent Lian Ouyang
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14 ; A61K51/04 ; C22B59/00 ; A61K33/24

Abstract:
The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
Public/Granted literature
- US20200030464A1 Stable, concentrated radionuclide complex solutions Public/Granted day:2020-01-30
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