A method for neuromodulation includes monitoring brain activity of a patient using one or more electrodes attached to the patient, and using a first machine learning model to predict whether a patient will have a seizure based on the monitored brain activity of the patient. The method also includes, responsive to the first machine learning model predicting that the patient will have a seizure, using a second machine learning model to determine a neuromodulation signal pattern for preventing the predicted seizure. The method further includes using a neurostimulator to apply the determined neuromodulation signal pattern to the patient. The method also includes, after applying the determined neuromodulation signal pattern to the patient, detecting whether the patient had the predicted seizure based on the monitored brain activity of the patient. The method further includes adjusting at least the second machine learning model based on whether the patient had the predicted seizure.