A vehicle lower portion structure has an internal combustion engine that is disposed on one side in a vehicle width direction in a power unit compartment, an inverter that is disposed on another side in the vehicle width direction in the power unit compartment, an exhaust pipe that extends in a vehicle front-rear direction through a dash panel separating the power unit compartment from a vehicle cabin, and is disposed within a floor tunnel that is provided in a central portion in the vehicle width direction at least at a position of the dash panel, and whose one end portion is connected to the internal combustion engine, a battery that is provided on a vehicle rear side of the dash panel, high-voltage power cables that extend in the vehicle front-rear direction on another side in the vehicle width direction and connect the inverter and the battery together.