Invention Grant
- Patent Title: Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
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Application No.: US16247354Application Date: 2019-01-14
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Publication No.: US10597381B2Publication Date: 2020-03-24
- Inventor: Brent R. Stockwell , Scott J. Dixon , Rachid Skouta
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Bryan Cave Leighton Paisner LLP
- Main IPC: C07C225/22
- IPC: C07C225/22 ; C07C69/78 ; A61K31/245 ; C07D401/12 ; C07C255/58 ; C07D213/80 ; C07C271/16 ; C07C271/24 ; C07C271/28 ; C07C205/57 ; C07C205/58 ; C07C211/50 ; C07D239/26 ; C07C229/60 ; C07C233/54 ; C07C237/30 ; C07D295/088 ; C07D211/58 ; C07D295/30 ; C07D213/36 ; C07D309/14 ; A61K31/325 ; A61K31/351 ; A61K31/4465 ; A61K31/495 ; A61K31/5375 ; A61K45/06 ; C07D295/192 ; A61K31/27 ; A61K31/44 ; A61K31/444 ; A61K31/4468 ; A61K31/505 ; A61K31/506 ; C07D213/74 ; C07D239/42
Abstract:
The present invention provides, inter alia, a compound having the structure: Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
Public/Granted literature
- US20190135782A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS Public/Granted day:2019-05-09
Information query
