Invention Grant
- Patent Title: Methods to treat lymphoplasmacytic lymphoma
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Application No.: US15904143Application Date: 2018-02-23
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Publication No.: US10597387B2Publication Date: 2020-03-24
- Inventor: Steven P. Treon , Sara Jean Buhrlage , Nathanael S. Gray , Li Tan , Guang Yang
- Applicant: Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07D409/04
- IPC: C07D409/04 ; C07D413/04 ; C07D401/04 ; C07D409/14 ; A61K31/496 ; A61K31/44 ; A61K31/4436 ; A61K31/4439 ; A61K31/4745 ; A61K45/06

Abstract:
The present invention provides compounds of any one of Formulae (I) to (V) (e.g., compounds of any one of Formulae (I-1) to (I-9)), and methods for treating Waldenström's macroglobulinemia (WM) and other B cell neoplams in a subject using the compounds. The methods comprise administering to a subject in need thereof an effective amount of the compounds. Also provided are methods to treat B cell neoplasms using the compounds in combination with inhibitors of Bruton's tyrosine kinase (BTK), interleukin-1 receptor-associated kinase 1 (IRAK1), interleukin-1 receptor-associated kinase 4 (IRAK4), bone marrow on X chromosome kinase (BMX), phosphoinositide 3-kinase (PI3K), transforming growth factor b-activated kinase-1 (TAK1), and/or a Src family kinase.
Public/Granted literature
- US20180186780A1 METHODS TO TREAT LYMPHOPLASMACYTIC LYMPHOMA Public/Granted day:2018-07-05
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