Invention Grant
- Patent Title: Adenine conjugate compounds and their use as vaccine adjuvants
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Application No.: US15763982Application Date: 2016-09-28
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Publication No.: US10597397B2Publication Date: 2020-03-24
- Inventor: Hitoshi Ban , Yukihiro Nishio , Padma Malyala , Bilikallahalli K. Muralidhara , Marcus Wong
- Applicant: Sumitomo Dainippon Pharma Co., Ltd. , AstraZeneca Aktiebolag
- Applicant Address: JP Osaka
- Assignee: Sumitomo Dainippon Pharma Co., Ltd.
- Current Assignee: Sumitomo Dainippon Pharma Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Fish & Richardson P.C.
- International Application: PCT/JP2016/004375 WO 20160928
- International Announcement: WO2017/056494 WO 20170406
- Main IPC: C07D473/18
- IPC: C07D473/18 ; A61K31/522 ; A61K31/54 ; A61K31/59 ; A61P35/00 ; C07D473/34 ; A61K47/54 ; A61K47/69 ; A61K39/12 ; A61K39/39 ; A61K39/00

Abstract:
The present specification relates to adenine conjugate compounds represented by the formula (1), wherein A, L1, L2, X1, R1, R2, R3, and m are as defined herein, or their pharmaceutically acceptable salts. Compounds of formula (1) have immunostimulating properties and may therefore be useful in therapy, for example as vaccine adjuvants. The present specification also relates to a process for preparing adenine conjugate compounds and pharmaceutically acceptable salts thereof, and to pharmaceutical compositions comprising adenine conjugate compounds and their pharmaceutically acceptable salts.
Public/Granted literature
- US20180282334A1 ADENINE CONJUGATE COMPOUNDS AND THEIR USE AS VACCINE ADJUVANTS Public/Granted day:2018-10-04
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