Invention Grant
- Patent Title: Protected monomer and method of final deprotection for RNA synthesis
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Application No.: US15839547Application Date: 2017-12-12
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Publication No.: US10597421B2Publication Date: 2020-03-24
- Inventor: Douglas J. Dellinger , Joel Myerson , Agnieszka Sierzchala , Geraldine F. Dellinger , Zoltan Timar
- Applicant: Agilent Technologies, Inc.
- Applicant Address: US CA Santa Clara
- Assignee: Agilent Technologies, Inc.
- Current Assignee: Agilent Technologies, Inc.
- Current Assignee Address: US CA Santa Clara
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; C07H21/00 ; C08L85/02 ; C07H19/067 ; C07H13/12 ; A61K31/7125 ; A61K31/712 ; C07H19/00 ; C07H19/167 ; C07H23/00 ; C07H1/00
Abstract:
A method of deprotecting a solid support bound polynucleotide comprising at least one 2′-protected ribonucleotide in which a step of contacting the polynucleotide with a composition comprising a diamine is performed under conditions sufficient to deprotect and cleave the polynucleotide which remains retained on the solid support.
Public/Granted literature
- US20180186826A1 PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS Public/Granted day:2018-07-05
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