- Patent Title: Biparatopic polypeptides antagonizing Wnt signaling in tumor cells
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Application No.: US15367323Application Date: 2016-12-02
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Publication No.: US10597449B2Publication Date: 2020-03-24
- Inventor: Vittoria Zinzalla , Klaus-Peter Kuenkele , Marie-Ange Buyse , Karen Cromie , Stephanie Staelens , Beatrijs Strubbe
- Applicant: Boehringer Ingelheim International GmbH
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Wendy M. Gombert
- Priority: EP15197999 20151204
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K16/28 ; C07K16/18

Abstract:
The invention provides novel biparatopic LRP5/LRP6 cross-reactive binding polypeptides, and more specifically novel biparatopic LRP5/LRP6 cross-reactive immunoglobulin single variable domain constructs which can inhibit Wnt signaling pathways. The invention also relates to specific sequences of such polypeptides, methods of their production, and methods of using them, including methods of treatment of diseases such as cancer.
Public/Granted literature
- US20170174762A1 BIPARATOPIC POLYPEPTIDES ANTAGONIZING WNT SIGNALING IN TUMOR CELLS Public/Granted day:2017-06-22
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