A plectrum for strumming a stringed instrument comprises a body having a front side, a rear side, a center portion, and a periphery. The body has one or more pick tips having an edge adapted to strum a stringed instrument. An ergonomic contour is provided on the front side and/or the rear side of the body, the ergonomic contour having a protrusion that extends radially from the center portion toward the periphery, the protrusion having one or more projections or recesses. The ergonomic contour creates a surface that is contactable by the thumb or other finger of a user to aid in the gripping of the plectrum and reducing stress. The pick tips on the body may each be different. A method of using the plectrum includes rotating the plectrum between the fingers from one pick tip to another.