Embodiments of the present invention provide a noise cancellation system, comprising noise cancellation parameter selection means for receiving data indicative of one or more operating conditions associated with a vehicle and selecting one or more noise cancellation configuration parameters based thereon, and noise cancellation means for receiving one or more noise signals, determining an in-vehicle noise cancellation signal based on the one or more noise signals according to the one or more configuration parameters and outputting the in-vehicle noise cancellation signal for reducing noise in the vehicle.