An instrumentation amplifier configured for providing high common mode rejection and low distortion is described and includes an input differential pair configured to receive a differential input voltage and differential feedback voltage and a folded cascode amplifying stage configured to receive output current mode signals provided from the input differential pair. A current mirror is configured to mirror output current mode signals provided from said folded cascode amplifying stage. An external gain setting configuration may include a resistor feedback network, which includes a first resistor being connected between feedback inputs of said input differential pair, a second resistor between an output terminal of the current mirror and a first feedback input of said input differential pair, a third resistor between a common terminal and a second feedback input of said input differential pair.