Methods and systems are described for receiving a plurality of signals corresponding to symbols of a codeword on a plurality of wires of a multi-wire bus, and responsively generating a plurality of sub-channel outputs using a plurality of multi-input comparators (MICs) connected to the plurality of wires of the multi-wire bus, generating a plurality of wire-specific skew control signals, each wire-specific skew control signal of the plurality of wire-specific skew control signals generated by combining (i) one or more sub-channel specific skew measurement signals associated with corresponding sub-channel outputs undergoing a transition and (ii) a corresponding wire-specific transition delta, and providing the plurality of wire-specific skew control signals to respective wire-skew control elements to adjust wire-specific skew.