Invention Grant
- Patent Title: Compounds for imaging tau proteins that accumulate in the brain
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Application No.: US14346914Application Date: 2012-12-21
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Publication No.: US10604516B2Publication Date: 2020-03-31
- Inventor: Makoto Higuchi , Tetsuya Suhara , Masahiro Maruyama , Meiei Cho , Hitoshi Shimada
- Applicant: National Institutes for Quantum and Radiological Science and Technology
- Applicant Address: JP
- Assignee: National Institutes for Quantum and Radiological Science and Technology
- Current Assignee: National Institutes for Quantum and Radiological Science and Technology
- Current Assignee Address: JP
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo PC
- International Application: PCT/JP2012/083286 WO 20121221
- International Announcement: WO2014/097474 WO 20140626
- Main IPC: A61B8/00
- IPC: A61B8/00 ; A61B5/00 ; A61B10/00 ; C07D417/06 ; C07F7/18 ; C07D401/06 ; C07D405/06 ; C07D417/14 ; C07D277/64 ; A61K49/00 ; C07D401/14 ; C07D405/14

Abstract:
The present invention provides a compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. wherein: R1 and R2 are each separately selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; ring A is a benzene ring or a pyridine ring; ring B is selected from the group consisting of the following formulas (i), (ii), (iii), and (iv): in the formula (ii), Ra is alkyl; R4 and R5 are each separately selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl; and [Formula 3] represents a double bond or a triple bond. The above compound can be used as a molecular probe for imaging tau proteins that accumulate in the brain.
Public/Granted literature
- US20150239878A1 Novel Compounds for Imaging Tau Proteins That Accumulate In Brain Public/Granted day:2015-08-27
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